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Various types of machines have been used for dividing and packing of powders and granules in most hospital pharmacies. It is essential that powders and granules should be accurately divided by machine. Comparative studies were performed to compare the weight variations using the following ３ machines １）Konishi KC 800－K 16 type(K）equipped with a linear vibrator to feed powders 2) Tousho VS－42 type(V), and 3) Hyup-Shin UP501－45E type(H). Four types of digoxin preparations were tested 1) 10,000 times dilution with powdered simple lactose(D-1), 2) 10,000 times dilution with equal dose of powdered simple lactose and fine granuled lactose(D-2), 3) 10,000 times dilution with fine granuled lactose(D-3), and 4) Rizaben^(®) granule(D-4). Fifteen grams of the each sample were divided into 15 parts by leach of the machines, and the process of dividing was repeated 10 times. The machine V showed the smallest weight variations after division than 3 other machines. The coefficients of variation of weight were 2.0∼15.2, 1.0∼6.1, 5.0∼10.2 and 2.0∼5.3％ for D-1, D-2, D-3 and D-4, respectively.
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